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yanping wang, md curriculum vitae
0000 xxxxxx xxxx , xxxx , xxxxx 00000
xxx-xxx-xxxx
abc@xyz.com
profile
senior research associate eager to contribute expertise in academic and industrial research toward actively supporting a leading-edge biopharmaceutical firm in identifying and facilitating pioneering scientific and technological innovations to optimize quality of human lives. offer qualifications that include, among others:
ø expertise in life science, cell biology and biochemistry
ø a decade of successful experience in animal model, primary stem cell culture and varied in vivo and vitro assays
ø m.s. in surgery and m.d. in clinical medicine, with eight years of practical clinical experience in surgery, gynecology and obstetrics
ø dynamic project management skills, with ability to effectively plan, coordinate and steer projects to achieve crucial timelines and goals
ø proactive leader and collaborative team player equally effective in self-directed and managed environments
animal experiment background
strong hands-on experience in a variety of animal models such as diabetic scid mice, c57bl mice and rats, acute liver failure mouse model, and acute and chronic stress models, among others.
proficient in rodent handling including injections (ip, iv, icv and sc), surgical procedures, behavioral and pharmacological study, tissue/blood sample collections, and perfusion.
advanced skills in cell isolation and purification from human, rat and mouse organs.
expertise in the transplantation of cells and tissues intraperitoneally (ip) or under the kidney capsules of rats and mice (ukc); adept in macro and micro encapsulation techniques.
solid background in glucose tolerance testing (gtt) including ogtt and ivgtt.
research skills
cell biology
extensive experience in conducting cell culture under gmp standard; skilled in cell proliferation and differentiation.
excel in developing, validating and performing varied cell-based assays such as cell growth viability, apoptosis assays; experience includes sgs (static glucose stimulation), facs, magnetic cell sorting, elisa, and dna cyquant quantification, etc.
histology
proficient in tissue and cells fixing, embedding, sectioning, he staining, immunohistochemistry (immunofluorescence and immunoperoxidase), microscopy and photography.
molecular biology
comprehensive background in total rna extraction, cdna synthesis, agarose gel, densitometry analysis, rt-pcr, and real time pcr.
page 1 of 3
yanping wang, md cv-page 2 of 3
career path
amcyte diabetes inc (acquired by reneuron at 2007), santa monica, ca 1998-current
research scientist; focus of research: (1) isolation, in vitro expansion and characterization of human pancreatic progenitor cells. (2) human embryonic stem cell culture, differentiation and characterization
effectively identify, select and proliferate endocrine progenitor cells from human adult pancreatic cell populations and differentiate into functional insulin-producing cells or islet-like cell clusters.
proficiently isolate and clone differentiation medium-responsive cell populations in support of generating new cell lines.
actively support multiple research projects by developing, optimizing and conducting a variety of cell based assays.
hold full accountability for ensuring islet isolation and purification from rat, mouse and human pancreases is in critical compliance with sop, safety and gmp clinical manufacturing guidelines.
perform in vitro culture of pancreatic progenitor cell in gmp environment as well as in vivo pharmacological evaluation of efficiency of islet transplantation in diabetic therapy.
successfully develop assays to effectively evaluate ammonia detoxification and albumin secretion of cultured rat liver cells.
steered investigation of isoforms and distribution of cell surface markers, such as ncam in human pancreatic cells.
cure, digestive diseases research center, dept. of medicine, ucla 1997-1998
research associate; focus of research: expression of a new neuropeptide pituitary adenylate cyclase activating polypeptide (pacap) receptor (paci) in gastrointestinal tract
effectively detected expression of pac i splice variants in purified ecl cells by immunohistochemistry and rt-pcr and defined the effects of pacap on acid secretion.
department of general surgery, baogang third hospital, baotou, p.r. china 1995-1997
attending surgeon; research focus: effects of cholecystectomy on gastrointestinal function
efficiently assessed duodenogastric reflex (dgr) through 24-hour continuous intragastric monitoring of ph value and gastrointestinal hormones both pre- and post-cholecystactomy.
department of general surgery, baogang third hospital, baotou, p.r. china 1984-1992
resident/attending physician
launched and built successful career in clinical practice.
education
m.s., surgery, tianjin medical university, tianjin, p. r. china; 1995
m.d., clinical medicine, baotou medical college, baotou, p.r. china; 1984
patents
wen-ghih tsang . tianli zheng and yanping wang. cultured and encapsulated pancreatic stem cells. international publication number wo03/059072 ai.
wen-ghih tsang . tianli zheng and yanping wang. in situ maturation of cultured pancreatic stem cells having a specified intermediate stage of development. us patent publication number 10/0000 xxxxxx xxxx , xxxx , xxxxx 000004-000700 us (pending).
wen-ghih tsang . hong-jung chen. yiping tu and yanping wang. methods of selecting pancreatic endocrine cells using protein synthesis inhibitors. 021164-000500 us (pending).
yanping wang, md cv-page 3 of 3
publications/abstracts
wen-ghih tsang ,tianli zheng, yanping wang, jinghua tang, howard rind, aleksandar
francki and nataliya bufius. culture and intracapsular aggregation of adult human
pancreatic islet tissue. transplantation. volume 83, number 6, march 27, 2007
yanping wang, baochang lui and qingrui li. the effect of gastrointestinal hormones on
gallbladder and bile duct. guo wai yi xue endocrinology. 1996: 15(4): 211-215
n zeng, t kang, rm luy, ga ohning, yp wang, jh wash, g sachs and jr pisegna.
pituitary adenylate cyclase activating peptide (pacap): the candidate peptide for central
regulation of gastric and secretion. annual meeting of american gastroenterological
association, new orleans, may 16-22, 1998.
w.g. tsang, c.c. huntenburg, t. zheng, a. schaeffer, y.p. wang, k. lim e. leoncio and p. tram. development of encapsulated human islets: effect of material selection on product performance. nih workshop-immununilisolation, washington dc, march 29-30, 2004.
wen-ghih tsang, tianli zheng, yanping wang and nataliya bufius. in vitro generated
islet-like-clusters exhibit similar cellular architecture and function to cultured
encapsulated islets. diabetes volume 53 supplement 2 :a455, 2004
wen-ghih tsang, carolyn c. huntenburg, tianli zheng, andrew schaeffer, yanping wang
and kermit lim. in vitro and in vivo characterization of the encapsulated islet for the clinical
trial entitled prospective phase i/ii safety study of encapsulated isolated primary human
pancreatic islet transplantation with low dose short term immune suppression in patients
with type i diabetes mellitus american transplant congress, boston, ma, may 14 c
19,2004.
w. tsang, t. zheng, y. wang, n. bufius, h. chen. in vitro proliferation of human pancreatic islet cells and assembly into functional islet-like clusters. the 44th ascb annual meeting in washington dc, 2004
hong-jung chen, wen-ghih tsang, tianli zheng, yanping wang, nataliya bufius, wen
chen, zhi-duan zhong, jinghua tang. proliferation of adult human endocrine progenitor
cells and differentiation into functional islet-like clusters. the 3rd isscr annual meeting
in san francisco, 2005.
hong-jung chen, yiping tu, yanping wang, jennitte stevens, aleksandar francki,
wen-ghih tsang. selection of pancreatic endocrine lineage cells using protein
synthesis inhibitor. the 4th isscr annual meeting in toronto, 2006
aleksandar francki, zhi-duan zhong, wen chen, yanping wang, jinghua tang, erik pong, andrew schaeffer, wen g. tsang. expression of ncam in cultured adult human pancreatic cells delineates mature endocrine cells as well as putative progenitors. 2006, american diabetes association 66th scientific sessions, washington dc
hong-jung chen, yiping tu, erik pong, yanping wang, wen chen, anakim chew, nataliya buffius, hui-ren liu, aleksandar franki, zhi-duan zhong, wen-ghih tsang;. proliferation and in vivo differentiation of selected adult human pancreatic endocrine progenitor cells. 2006, 7th annual rachmiel levine symposium, anaheim, ca.
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