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Yyyyyy x. yyyyyy

0000 xxxxxx xxxx , xxxx , xxxxx 00000

abc@xyz.com

(xxx-xxx-xxxx

Country of Citizenship: United States

Veteran s Preference: N/A

 

Usajobs.com Announcement #: HHS-FDA-09-2008-0143

 

Core Qualifications/Competencies

 

Senior Pharmacologist, Senior Toxicologist, Primary Investigator, Pre-Clinical Pharmacology, Clinical Pharmacology, Product Development, Research and Development (R&D), Drug Discovery, Drug Safety, Study/Research Protocol, Report Reviews, Data Interpretation, Product Identification, Health Scientist, Widely Published, Frequent Invited Speaker

 

Professional Experience

 

2000 - present

National Institute on Drug Abuse (NIDA), NIH

Bethesda, MD

Division of Pharmacotherapies & Medical Consequences of Drug Abuse (DPMCDA)

Medications Discovery & Toxicology Branch

Supervisor: David J. McCann, Ph.D.; Phone xxx-xxx-xxxx ; Permission to Contact: Yes

Annual Salary: $127K

Hours per week: 40

Health Scientist Administrator

Have proficiently established a cardiovascular drug safety evaluation program, strategically collaborating with invited industry, FDA and academia leaders to define and address key health assessment issues impacting QT/QTc prolongation.  Developed in vitro/in vivo studies protocol to evaluate cardiovascular safety studies, with a strong focus on cocaine-medication interactions in monkeys and dogs. Efficiently reviewed and summarized findings/results from toxicology, pharmacokinetic, and toxicokinetic studies conducted under research contracts and in conjunction with projects within the DPMCDA; data from over 150 studies have been subsequently applied toward filing Investigational New Drug Application (INDs) for drug addiction treatment.  Applied strong research and analysis skills toward reviewing literature in order to identify medications with novel mode of action that may present potential for preventative and therapeutic treatment of addictive disorders, including food addiction.

1999 - 2000

American Chemistry Council

Arlington, VA

Panel Manager

Comprehensively analyzed, troubleshot and resolved critical issues associated with mammalian toxicology, public health, environment, government, and chemical industry to define optimal research, education and advocacy strategies.  Conducted thorough reviews of toxicology reports on fluoro-alkenes and hydrogen sulfide; compiled data and summarized findings for submission to Environmental Protection Agency (EPA). 

 

 

 

 

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Professional Experience continued

 

1996 - 1999

Otsuka America Pharmaceutical Inc

Rockville, MD

Supervisor : Norma Browder; Phone: 301-990-0030; Permission to Contact: Yes

Annual Salary: $105K

Hours per week: 40

Associate Director of Drug Safety Evaluation

Studied broad scope of drug candidates for treatment of diverse health/medical issues ranging from congestive heart failure and intermittent claudication to stroke, stenosis and restenosis; research included diuretic pharmaceuticals.

Actively collaborated in preparing Investigational New Drug Applications (INDs), Investigational Drug Brochures (IDBs) and New Drug Applications (NDAs) for multiple cardiovascular drugs.  Contributed dynamic leadership skills toward steering contract research laboratory operations targeting evaluation of drug safety and efficacy.  Instrumental in attaining approval of Cilostazol (Pletal) for United States as well as global countries.

 

1981 - 1994

Carter Wallace, Inc.

Cranbury, NJ

Supervisor: Dr. Duane Sofia, Retired; Home Phone: 717-569-4144; Permission to Contact: Yes

Annual Salary: $110K

Hours per week: 40

Director, Department of Pharmacology; 1992-1994

Associate Director, Department of Pharmacology; 1988-1992

Section Leader; 1983-1988

Senior Pharmacologist; 1981-1983

Steadily progressed with company over the course of 13 years, culminating in senior-level position as Director of Pharmacology Department.  Led laboratory operations and contract research initiatives, evaluating activity and commercial merits of licensing and acquiring varied compounds. Applied dynamic leadership skills toward effectively directing a top-performing team of research scientists in facilitating complex pharmacological and toxicological studies.  Effectively developed/prepared numerous reports, summaries, INDs, and IDBs leading to NDA submissions of anti-allergy, anti-asthma and neuro-protective drugs to US FDA; successfully made a significant contribution to NDA approval of azelastine in Japan and Germany as well as US drugs, Astelin and Felbatol.

 

Education

 

University of Guelph, Ontario, Canada

Doctor of Philosophy, Pharmacology

Date: 1978

 

University of Guelph, Ontario, Canada

Masters of Science, Pharmacology

Date: 1974

Total Credits: 37.5

Key Coursework: Cardiovascular Physiology, Special Problems in Biomedical Sciences, Medical Immunology, Advanced Pharmacology II

U.P. Agricultural University, Nainital, India

Masters in Veterinary Science, Pharmacology/Toxicology

Date: 1971

Total Credits: 43

Key Coursework: Correlative Pathology, Pharmacology, Biochemistry, Organic Chemistry, Intermediate Metabolism of Carbohydrates and Fats

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Education continued

 

U.P. Agricultural University, Nainital, India

Doctor of Veterinary Medicine

Date: 1969

Total Credits: 150

Key Coursework: Anatomy, Histology, Physiology, Pathology, Necropsy, Medicine, Surgery, Nutrition

GPA: 4.99/5.0

 

(Academic Background Details Referenced, WORLD EDUCATION SERVICE REPORT, pp 1-7)

 

Honors/Awards

 

Graduated 1st in Class amongst 150 Students, DVM Program

Recipient, Gold Medal Award for highest GPA (4.99/5.0)

Donald McQueen Shaver Award, Canada

Senior Research Fellowship, India

Junior Research Fellowship, India

 

Selected Publications

(10 of 73 in vivo and in vitro publications)

 

Chand, N., Nolan, K., Pillar, J., Diamantis, W. and Sofia, R.D. (1992).  Aeroallergen-induced dyspnea in freely moving guinea pigs:  Quantitative measurement by bias flow ventilated whole body plethysmography.  Allergy 48:230-235.

 

Chand, N., Nolan, K., Diamantis, W., Perhach, J.L. Jr. and Sofia, R.D. (1986).  Inhibition of leukotriene (SRS-A)-mediated acute lung anaphylaxis by azelastine in guinea pigs.  Allergy 41:473-478.

 

Chand, N., Pillar, J., Diamantis, W., Perhach, J.L. Jr. and Sofia, R.D. (1983).  Inhibition of calcium ionophore (A23187)-stimulated histamine release from rat peritoneal mast cells by azelastine:  Implications for its mode of action.  Eur. J. Pharmacol. 96:227-233.

 

Chand, N., Adusumalli, V.E., Nolan, K., Diamantis, W., Wichmann, J.K., Pivonka, J., Langevin, C.N., Wong, K.K., Kucharczyk, N. and Sofia, R.D. (1983).  Pharmacodynamic and pharmacokinetic studies with azelastine in the guinea pig:  Evidence for preferential distribution into the lung.  Allergy. 48:19-24.

 

Chand, N. and Altura, B.M. (1981).  Acetylcholine and bradykinin induce relaxation of intrapulmonary arteries by acting on endothelial cells:  Role in lung vascular diseases.  Science 213:1376-1379.

 

Chand, N. (1981).  Reactivity of isolated trachea, bronchus and lung strip of cats to carbachol, 5-hydroxytryptamine and histamine:  Evidence for the existence of methysergide sensitive receptors.  Br. J. Pharmacol. 73:853-857

 

Chand, N., Dhawan, B.N., Srimal, R.D., Rahmani, N.H., Shukla, R.K. and Altura, B.M. (1981).  Reactivity of airway smooth muscles to bronchoactive agents in langur monkeys.  J. Appl. Physiol. 50:513-516.

 

Chand, N., Dhawan, B.N., Srimal, R.C., Rahmani, N.H. Shukla, R.K. and Altura, B.M. (1980).  Reactivity of trachea, bronchi, and lung strips to histamine and carbachol in rhesus monkeys.  J. Appl. Physiol. 49:729-734.

 

Chand, N. and Altura, B.M. (1980).  Reactivity and contractility of rat main pulmonary artery to vasoactive agents.  J. Appl. Physiol. 49:1016-1021.

 

Chand, N. and DeRoth, L. (1979).  Dual histamine receptor mechanism in guinea-pig lung.  Pharmacology 19:185-190

 

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Invited Lectures 

(Selected 3 of 23)

 

Invited Faculty, North American Society for Pacing and Electrophysiology, 24th Annual Scientific Sessions. May 2003. 

GBR 12909 (Vanorexine)- pharmacokinetic and toxicokinetic data in relation to QT prolongation.  Session on QT Prolonging Drugs - Basic, Clinical and Regulatory Issues. 

 

Medical consequences of obesity and food addiction. Eagleville Hospital, Eagleville, Pennsylvania (April 28, 2006). Prevention of obesity and food addiction. Institute of Management Studies (IMS), Ghaziabad, U.P., India (November 12th, 2007).

 

IL-5 antibodies and modulation of bronchial eosinophilia. FASEB Summer Research Conference, Sextons River, Vermont (July 10th -15th , 1993).

 

Book Chapters and Review Articles 

(Selected 6 of 15)

 

Chand, N. and Sofia, R.D. (1994). Histamine: Receptor Subtypes, Signal Transduction and Airway Effects: Airways Smooth Muscle, Vol. 3, ed. D. Raeburn and M.A. Giembycz, Birkhauser, Verlag, AG, Basel, Switzerland.

 

Chand, N. and Sofia, R.D. (1993). Potential Therapeutic Usefulness of Anti-IL-5 Monoclonal Antibody in Asthma. Drugs of Today 29:477-485

 

Chand, N. and Sofia, R.D. (1993). Potential Therapeutic Usefulness of Anti-IL-5 Monoclonal Antibody in Asthma. Drugs of Today 29:477-485.

 

Chand, N., Diamantis, W. and Sofia, R.D. (1990). Airway histamine receptors and their significance in allergic lung diseases. In: Airway smooth muscle: modulation of receptors and response, ed. D.K. Agrawal and R.G. Townley, CRC Press, Inc., p. 259-269.

 

Perhach, J.L., Chand, N., Diamantis, W., Sofia, R.D. and Rosenberg, A. (1989).  Azelastine - a novel oral antiasthma compound with several modes of action.  In: Allergy and Asthma - New Trends and Approaches to Therapy, Ed. A.B. Kay, Blackwell Scientific Publications, p. 230-248.

 

Chand, N., Perhach, J.L., Jr., Diamantis, W. and Sofia, R.D. (1985).  Heterogeneity of calcium channels in mast cells and basophils and the possible relevance to pathophysiology of lung diseases:  A Review.  Agents and Actions 17:407-417.

 

Continuing Medical Education/CMEs

 

Coursework

QT and Arrhythmia Issues in Drug Development, FDA/Heart Rhythm Society,

April 7th-8th, 2008

Genetics and Epigenetic of Addiction, NIDA, March 31st - April 4th, 2008

Clinical Pharmacology - Data Analysis: Modeling and Simulation, NIH

October 20-21, 2004

Principles of Clinical Pharmacology, NIH, 2003

The Biologic and Medical Device Approval process, one week training course, August 2000

Regulatory Toxicology, Kansas City, MO, April 1999

 

Conferences

American Heart Association, Annual Scientific Sessions (1996 C present)

Attended many symposia on the pathphysiology of cardiovascular diseases, atherosclerosis and lipid disorders, metabolic syndrome, obesity etc.

 

 

Yyyyyy x. yyyyyy                                   HHS-FDA-09-2008-0143 - Page 5 of 5

 

Professional Affiliations

 

Association of Government Toxicologists (2000 C present)

-President; 2005

Councilmember, American Heart Association, Council on Arteriosclerosis, Thrombosis & Vascular Biology; Stroke; Circulation (1997 C 2000)

Pulmonary Research Group

-President, 1990 - 1996

-Board Member, 1996 C 1999

 

Key Specialties/Professional Interests

 

Preclinical and clinical pharmacology

Cardiovascular drug safety/toxicology

Cardiovascular diseases and aging

Obesity, metabolic syndrome, diabetes, osteoporosis

Inflammation, allergy, asthma

Drug discovery and development (R&D)

 

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