ALEXANDER USYATINSKY, Ph.D.XXXXXX YYYYYYYYyyyyy x. yyyyyy

Phone: (518) 283 3506xxx-xxx-xxxx                                                                                         6 Aaverlord Blvd.

Cell:     (518) 331 6553xxx-xxx-xxxx                                                                                         TroyXxxxxxXxxxxxXxxxxx, NYXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 12180xxxxxxxxxxxxxxxxxx0000 xxxxxx xxxx , xxxx , xxxxx 000000000 xxxxxx xxxx , xxxx , xxxxx 000000000 xxxxxx xxxx , xxxx , xxxxx 00000

e-mail: ausyatin@nyxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxcap.rr.comabc@xyz.comabc@xyz.comabc@xyz.com

Alexander Usyatinsky, Ph.D.XXXXXX YYYYYYYYyyyyy x. yyyyyy
6 Aavelord Blvd
TroyXxxxxxXxxxxxXxxxxx, NYXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 12180xxxxxxxxxxxxxxxxxx0000 xxxxxx xxxx , xxxx , xxxxx 000000000 xxxxxx xxxx , xxxx , xxxxx 000000000 xxxxxx xxxx , xxxx , xxxxx 00000
518-283-3506 xxx-xxx-xxxx xxx-xxx-xxxx

518-331-6553 xxx-xxx-xxxx  xxx-xxx-xxxx
ausyatin@nyxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxcap.rr.comabc@xyz.comabc@xyz.comabc@xyz.com

Country of Citizenship: United States

 

 

Core Competencxxxxxxies

Patent Examination; Chemistry; Chemical Engineering; Medicinal Chemistry; Synthetic Organic Chemistry; Organometallic Chemistry; Scientific Research; Scientific Data Analysis; Biological Data Evaluation; Scientific Information Editing; Scientific Writing; Compound Isolation; Multi-Step Organic Synthesis; Microwave Assisted Solution Free Synthesis; Main Group Metals and Boronorganic Compounds Synthesis; Drug Discovery; Product Development; R&D; Project Management; Laboratory Management; Synthesis Methodology; Active Structure Development; SAR Studies; Presentations & Discussions; Teaching; Team Leadership; Training/Mentorship; Client Communications; Customer Relations

 

 

SUMMARY OF QUALIFICATIONS:

Extensive experiencxxxxxxe in medicinal, synthetic organic and organometallic chemistry

Specializing in multistep organic synthesis, microwave assisted solution free synthesis, synthesis of main group metals- and boronorganic compounds

Experiencxxxxxxe in scientific information analysis and editorial work

Foreign languages proficiencxxxxxxy: Russian, Ukrainian (fluent), Polish, Serbo-Croatian.

       

.                                           

EMPLOYMENTEmployment BackgroundEMPLOYMENT:

 

02/2010-present

GE Global Research Center/ Yoh (Contractor)

Niskayuna, New YorkXxxxxxXxxxxxXxxxxxXxxxxxXxxxxx US

Hours per Week: 40

Salary: 40/hour USD

Supervisor: Dr. Grigorii Soloveichik (518) 387-7906 xxx-xxx-xxxx ; May contact

2010-present

Chemist-Temporary

Proficiently devise synthesis of ligands and organometallic catalysts supporting fuel cells-based energy devices for Energy Frontier Research Center.

Devised synthesis of ligands and organometallic catalysts for fuel cells based energy devices

 

 

08/2001- 08/2009                              

Albanyxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx Molecular Research Incxxxxxx. (AMRI)

, Albanyxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx, New YorkXxxxxxXxxxxxXxxxxxXxxxxxXxxxxx

Senior Research Scientist     Department of Medicinal Chemistry/Drug Discovery

                                                        Research and Development

Albanyxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx, New YorkXxxxxxXxxxxxXxxxxxXxxxxxXxxxxx US

Hours per Week: 40

Salary: 78,800/annual USD

Supervisor: Mathew Surman (518) 464-0279 xxx-xxx-xxxx ; May Contact

Senior Research Scientist    

 

Page 1 of 4

Alexander Usyatinsky, Ph.D.XXXXXX YYYYYYYYyyyyy x. yyyyyy                                                                                           Page 2 of 4

Retained after EnzyMed buyout and merger with AMRI to oversee client engagements as well as internal R&D projects; consistently ensured achievement of critical customer specifications and deadlines through strategic coordination, scheduling and management of multi-task workflow.  Conferred with clients throughout projects and delivered routine progress reports. Successfully collaborated with major pharmaceutical firms in developing and synthesizing

Developed and synthesized potential drug candidates, playing a key role in generating profits for both client and AMRI. Effectively improved on customer-proposed compounds to achieve targets in developing new structures and synthesizing a series of active drug candidates; optimal candidate currently in Stage I & II clinical trials with another licensed by customers to Gilead Sciencxxxxxxes.

 

Targeting Cystic Fibrosis and Chronic Broncxxxxxxhitis treatments, e in collaboration with major pharmaceutical companies;

Elucidated synthesis and SAR of novel substituted pyrazinoylguanidines as a sodium channel blockers.  Developed project from 3-month customer contract supported by 1 chemist to 5-year contract employing 8 full-time staff.

 

Efficiently c for the treatment of cystic fibrosis and chronic broncxxxxxxhitis.

Conducted synthesis and investigated of structure/-activity relationship of new 5-HT3 antagonists/partial agonists as potential drugs for applications in against IBS-D and IBS-C; developed new compound with strong potential for conditions and as a result, identified drug with applications in preventing emesis in cancxxxxxxer patients undergoing chemotherapy. .

DDeveloped synthesis and investigated SAR of non-steroidal anti-inflammatory agents.

 

Designed new, scalable synthesis methodology for synthesized active metabolite.  Created pharmacologically-acceptable form of product by establishing an effective method.  In support of major obesity project, derived new synthetic method for preparation of a backup candidate that could not be synthesized using the primary method due to structural differencxxxxxxes.

01/1995-08/2000                                

EnzyMed Incxxxxxx.

, Iowa City, Iowa US

Hours per Week: 40

Salary: 53K/annual USD

Supervisor: Dr. Yuri Khmelnitsky (518) 512-2890 xxx-xxx-xxxx ; May Contact

Senior Scientist, Scientist ,Scientist, Industrial Post-Doctoral Fellow

Strategically applied Applied microwave activation to heterocyclic condensation reactions in combinatorial format. D

Developed methodology  a method for scavenging excess of acyl donors with solid phase reagents.

Synthesized Conducted synthesis of Paclitaxel (Taxol) derivatives with incxxxxxxreased water solubility.

 

08/1976-04/1994                            

Russian Academy of Sciencxxxxxxes

A.N. Senior Research Associate    Nesmeyanov Institute of Organo-Element Compounds,

Research Associate                Moscow, Russia    

Hours per Week: 40

Salary: 300/month RUB

Supervisor: Prof. Vladimir Bregadze 7-495-934-3067; May Contact

Senior Research Associate      

Developed novel mercury and thallium derivatives of carboranes/metallocarboranes as well as clearly defined nd determined their stereo and regiochemistry.  Resourcefully created enhancxxxxxxed

Created an improved thallation methodology towardss the synthesis of organoboron compounds.

Designed efficient method for separating veloped method to separate a mixture of  C60of C60 and C70 fullerenes. In support of cancxxxxxxer therapy,

sSynthesized novel boron-containing compounds for neutron capture. Effectively e cancxxxxxxer therapy.developed

Developed mechano-chemical methods focused on isolatingr the isolation of thallium from waste.

Alexander Usyatinsky, Ph.D.XXXXXX YYYYYYYYyyyyy x. yyyyyy                                                                                           Page 3 of 4

Concxxxxxxurrently contributed subject matter expertise and dynamic communication skills toward delivering student classroom instruction and facilitating lab supervision in General Organic Chemistry Taught general organic chemistry and supervised laboratory classes for students at of G.I. Plekhanov Russian Economic Academy.

 

;

Developed novel mercury and thallium derivatives of carboranes and metallocarboranes and studied their stereo- and regiochemistry and crystal structure.

Developed method of separation of fullerenes C60 and C70 using column chromatography.

Elucidated methods of synthesis of novel boron-containing compounds for the use in neutron capture cancxxxxxxer therapy.

 

10/1982-05/1990                              

Vsesoyuznyxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxi Institute Nauchno-Techniceskoi Informacii

                                                Referativnyxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxi Zhurnal Khimiya                           

Moscow, Russia

Hours per Week: 10

Salary: 30/month RUB

Supervisor: Alexander Ryabov (phone # N/A); May Contact

      Document Analysis Specialist (part time)

Expertly analyzed journal paper and patent Analyzed scientific information  from journal papers and patents in  synthetic organic chemistry,

      coordination compound chemistry and , chemical kinetics.

 

11/      1988-03/1993                     

Metaloorganicheskaya Khimiya

-      Editor (part time)             (Organometallic Chemistry in USSR

Moscow, Russia

Hours per Week: 10

Salary: 10/week RUB
Supervisor: Prof. Vladimir Bregadze 7-495-934-3067; May Contact)

Editor and       Reviewer (part time) 

Comprehensively rReviewed and proofread scientific content of papers submitted for publication.

the submitted papers and performed proofreading.

 

Education

DUCATION:

1984   Nesmeyanov Institute of Organo-Element Compounds

,Moscow, Russia

Degree:

          Ph.D. in Chemistry.

Earned: 1984

GPA: N/A-currently under review for US equivalencxxxxxxy ranking

TThesis: Carboranyxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxl Carboranyxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxl derivatives of thallium (III)

 

1976 M.V. Lomonosov  MoscowLomonosov Moscow State University

, Moscow, Russia

Degree:            M.Sc. in Chemistry

Earned: 1976

GPA: N/A-currently under review for US equivalencxxxxxxy ranking

 

PatentsPATENTS:

           

1. P.R. Guzzo,  M.D.Surman, M.D.Surman, Henderson A.J, M.X. Jiang, M. Hadden, J. Grabowski,      A.Usyatinsky, 1-Azinone)-substituted pyridonindoles

US Patent application 20090xxxxxx27559xxxxxx xxx-xxx-xxxx 0000 xxxxxx xxxx , xxxx , xxxxx 000000

2. Y.L. Khmelnitsky, C.L. Buddy, J.M. Arnold, J.O. Rich, S.S. Chen, A.Ya.  Usyatinsky, D.S.Clark, J.S.Dordick, Two Step Enzymatic Acylation US Patent 6,261,813 B1 0.7, 17, 2001.

3. S.H. Chen, C.S. Galka, S.L.Hellman, J.L. Krstenantsky, M.L. Rodrigues, J. Xicheng , A. Ya. Usyatinsky, V. Vasudevan, M.J. Zweifel Pseudomycin amid and ester analogs PCT WO 01/05817 A1 0.1 25, 2001.

Alexander Usyatinsky, Ph.D.XXXXXX YYYYYYYYyyyyy x. yyyyyy                                                                                           Page 4 of 4
US Patent 6,261,813 B1 0.7, 17, 2001

PCT WO 01/05817 A1 0.1 25, 2001

 

Publications/PresentationsPUBLICATIONS

:

More than 40 papers in International and Russian Journals as well as several presentations at International Conferencxxxxxxes-full listing available on request, with Most Recent incxxxxxxluding:

.

The most recent publications:

1. M. Bai, G. Carr, R.l J. DeOrazio  T. D. Friedrich , S Dobritsa, Kevin Fitzpatrick ,

P. R. Guzzo , D. B. Kitchen , M. A. Lyncxxxxxxh , D. Peace , M. Sajad, A. Usyatinsky, M. A. Wolf: 5-Funcxxxxxxtionalized indazoles as glucocorticoid receptor agonists. , Bioorg.Med.Chem.Lett., 2010, 20, 3017-3020.

 

2. A J. Hirsh, B. F. Molino, J. Zhang, N. Astakhova, W. B. Geiss, B. J. Sargent, B. D. Swenson, A.  Usyatinsky, M. J. Wyle, R. C. Boucher, R. T. Smith, A. Zamurus, and M. R. Johnson Design, Synthesis and Structure Activity Relationship on Novel 2-substituted  Pyrazinoylguanidine Epothelia Sodium Channel Blockers: Drug for Cystic Fibrosis and Chronic Broncxxxxxxhitis. J. Med. Chem, 2006, 49(14), 4098-4115.

 

3. A. Usyatinsky, N.A. Astakhova, Yu.L. Khmelnitsky Simple and Efficient Solid Support Scavenging of Excess Acyl Donors after Enzymatic Acylations in Organic Solvents , Biotechnology and Bioengineering, 2003, 82, 380-385.

 

4. A. Usyatinsky, Yu.L. Khmelnitsky Microwave assisted synthesis of substituted imidazoles on solid support under solvent free conditions , Tetrahedron Lett., 2000, 41, 5031-5034.

 

5. I.C. Cotterill, A.  Usyatinsky, J.M. Arnold, D.S. Clark, J.S. Dordick, P.C. Michels, Yu.L. Khmelnitsky Microwave Assisted Combinatorial Chemistry. Synthesis of Substituted Pyridines Tetrahedron Lett. 1998, 39, 1117-1120.

 

6. V.V.Mozhaev, C.L.Budde, J.O.Rich, A. Usyatinsky, P.C.Michels, Yu.L.Khmelnitsky, D.S.Clark, J.S.Dordick Regioselective Enzymatic Acylation as a Tool for Producing Solution Phase Combinatorial Libraries , Tetrahedron, 1998, 54, 3971-3982.

 

7. Yu.L. Khmelnitsky, C. Budde, J.M. Arnold, A. Usyatinsky, D.S. Clark, J.S. Dordick

Synthesis of Water Soluble Paclitaxel Derivatives by Enzymatic Acylation
J. Am. Chem. Soc. 1997, 119, 11554xxxxxx0000 xxxxxx xxxx , xxxx , xxxxx 00000-11555xxxxxx.

 

Languages

 

Multi-Lingual: English, Russian, Ukrainian, Polish, Serbo-Croatian

 

Professional Affiliations

 

Member, American Chemical Society
Member, Patroon Toastmasters Club

A J. Hirsh, B. F. Molino, J. Zhang, N. Astakhova, W. Geiss, B. Sargent, B. Swenson, A. Ya. Usyatinsky, M. J. Wyle, R. C. Boucher, R. T. Smith, A. Zamurus, and M. R. Johnson

Design, Synthesis and Structure Activity Relationship on Novel 2-substituted Pyrazinoylguanidine Epothelia Sodium Channel Blockers: Drug for Cystic Fibrosis and Chronic Broncxxxxxxhitis.

J.Med. Chem, 2006, 4098-4115

A.Ya. Usyatinsky, N.A. Astakhova, Yu.L. Khmelnitsky

Simple and Efficient Solid Support Scavenging of Excess Acyl Donors after Enzymatic Acylations in Organic Solvents

 Biotech logy and Bioengineering, 2003, 82, 380-385.

A.Ya. Usyatinsky, Yu.L. Khmelnitsky

Microwave assisted synthesis of substituted imidazoles on solid support under solvent free conditions

Tetrahedron Lett., 2000, 41, 5031-5034

I.C.Cotterill, A.Ya. Usyatinsky, J.M. Arnold, D.S. Clark, J.S. Dordick, P.C. Michels, Yu.L. Khmelnitsky

  Microwave Assisted Combinatorial Chemistry. Synthesis of Substituted Pyridines

Tetrahedron Lett. 1998, 39, 1117-1120.

V.V.Mozhaev, C.L.Budde, J.O.Rich, A.Ya. Usyatinsky, P.C.Michels, Yu.L.Khmelnitsky, D.S.Clark, J.S.Dordick

  Regioselective Enzymatic Acylation as a Tool for Producing Solution Phase Combinatorial Libraries Tetrahedron, 1998, 54, 3971-3982

 

 

 

 

 

 

 

 

 

Alexander Usyatinsky, Ph.D.XXXXXX YYYYYYYYyyyyy x. yyyyyy
6 Aavelord Blvd
TroyXxxxxxXxxxxxXxxxxx, NYXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 12180xxxxxxxxxxxxxxxxxx0000 xxxxxx xxxx , xxxx , xxxxx 000000000 xxxxxx xxxx , xxxx , xxxxx 000000000 xxxxxx xxxx , xxxx , xxxxx 00000
518-283-3506 xxx-xxx-xxxx xxx-xxx-xxxx

518-331-6553 xxx-xxx-xxxx  xxx-xxx-xxxx
ausyatin@nyxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxcap.rr.comabc@xyz.comabc@xyz.comabc@xyz.com

Country of Citizenship: United States

KSA

Ability to analyze and interpret written materials, incxxxxxxluding technical materials, rules, regulations, instructions, and reports.

Over the course of my extensive career in Scientific Research, the ability to effectively analyze and interpret a wide range of scientific data, technical materials, rules/regulations, instructions, and reports has been vital to successfully steering varied research and development projects.  With the bulk of my U.S. career as a Senior Research Scientist at Albanyxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx Molecular Research Incxxxxxx./EnzyMed Incxxxxxx. (1995-2009), my extensive involvement in collaborating with major pharmaceutical firms on crucial client engagements as well as steering independent R&D projects required ongoing analysis and interpretation of broad, complex written materials throughout project scope. 

 

Concxxxxxxurrent with my earlier career as a Senior Research Associate in Russia, I held positions specifically focused on the analysis and interpretation of scientific materials.  From 1982-1990 I was a part-time Document Analysis Specialist accountable for analyzing journal paper and patent scientific information focused on wide areas of chemistry. Within that time frame, 1988-1993, I was also a part-time Editor and Reviewer with Organometallic Chemistry in USSR, where I conducted thorough review, proofreading and editing of papers submitted for publication.

 

Complementing this, I have published over 40 papers in International and Russian journals as well as delivered numerous presentations at International Conferencxxxxxxes, again requiring extensive analysis and interpretation of complex written materials.  In earning several Patents, I relied heavily on accurate interpretation and application of stringent regulatory guidelines.  Similarly, proficient analysis and interpretation of scientific materials was vital in successfully developing, completing and presenting my Ph.D. Thesis in carboranyxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxl derivatives of thallium.

REFERENCXXXXXXES:  Available upon request.

 

PERSONAL          US Citizen